Differential expression of α-methylacyl-coenzyme A racemase in colorectal carcinoma bears clinical and pathologic significance
Lin A, Weiser M, Klimstra D, Paty P, Tang L, Al-Ahmadie H, Park S, Guillem J, Temple L, Wong W, Gerald W, Shia J. Differential expression of α-methylacyl-coenzyme A racemase in colorectal carcinoma bears clinical and pathologic significance. Human Pathology 2007, 38: 850-856. PMID: 17442371, DOI: 10.1016/j.humpath.2006.12.016.Peer-Reviewed Original ResearchConceptsAlpha-methylacyl-coenzyme A racemaseAmerican Joint Committee on CancerAlpha-methylacyl-coenzyme A racemase expressionDisease-specific survivalLow-intensity stainingColorectal carcinomaLymphovascular invasionPeroxisomal beta-oxidation of branched-chain fatty acidsAlpha-methylacyl coenzyme A racemase stainingOverexpression of alpha-methylacyl coenzyme A racemasePatient outcomesPathological characteristicsAmerican Joint Committee on Cancer stagePresence of lymphovascular invasionAssociated with prostate cancer progressionModerate to strong stainingHigher American Joint Committee on CancerTumor pathological characteristicsTumor pathologic featuresPrimary colorectal carcinomaProstate cancer progressionPoor tumor differentiationBeta-oxidation of branched-chain fatty acidsRed meatImmunohistochemical expression pattern
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