The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction
VanDusen K, Eleswarpu S, Moretti E, Devinney M, Crabtree D, Laskowitz D, Woldorff M, Roberts K, Whittle J, Browndyke J, Cooter M, Rockhold F, Anakwenze O, Bolognesi M, Easley M, Ferrandino M, Jiranek W, Berger M, Adams S, Amundsen C, Avasarala P, Barber M, Berchuck A, Blazer III D, Brassard R, Brigman B, Cai V, Christensen S, Cox M, Davidson B, DeOrio J, Erdmann D, Erickson M, Funk B, Gadsden J, Gage M, Gingrich J, Greenup R, Ha C, Habib A, Abi Hachem R, Hall A, Hartwig M, Havrilesky L, Heflin M, Holland C, Hollenbeck S, Hopkins T, Inman B, Jang D, Kahmke R, Karikari I, Kawasaki A, Klapper J, Klifto C, Klinger R, Knechtle S, Lagoo-Deenadayalan S, Lee W, Levinson H, Lewis B, Lidsky M, Lipkin M, Mantyh C, McDonald S, Migaly J, Miller T, Mithani S, Mosca P, Moul J, Novick T, Olson S, Pappas T, Park J, Peterson A, Phillips B, Polascik T, Potash P, Preminger G, Previs R, Robertson C, Scales Jr C, Shah K, Scheri R, Siddiqui N, Smani S, Southerland K, Stang M, Syed A, Szydlowska A, Thacker J, Terrando N, Toulgoat-DuBois Y, Visco A, Weidner A, Yanamadala M, Zani Jr S. The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction. Journal Of Alzheimer’s Disease 2020, 75: 1319-1328. PMID: 32417770, PMCID: PMC7923142, DOI: 10.3233/jad-191185.Peer-Reviewed Original ResearchConceptsPerioperative neurocognitive disordersAdverse event ratesCN-105Placebo-treated patientsDose-escalation trialPerioperative adverse event ratesEvent ratesPostoperative cognitive testingOlder surgical patientsPostoperative cognitive dysfunctionRandomized to controlPostoperative neuroinflammationEscalation trialNon-neurological surgeryReduced brain inflammationNon-cardiacPerioperative administrationPreventing PNDChart reviewSurgical patientsLong-term cognitive declineCSF analysisBrain inflammationRisk factorsSurgery
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