Enhanced interaction of HLA-DM with HLA-DR in enlarged vacuoles of hereditary and infectious lysosomal diseases.
Lem L, Riethof D, Scidmore-Carlson M, Griffiths G, Hackstadt T, Brodsky F. Enhanced interaction of HLA-DM with HLA-DR in enlarged vacuoles of hereditary and infectious lysosomal diseases. The Journal Of Immunology 1999, 162: 523-32. PMID: 9886429, DOI: 10.4049/jimmunol.162.1.523.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDAntigens, Differentiation, B-LymphocyteB-LymphocytesCell LineChediak-Higashi SyndromeChlamydia trachomatisCoxiellaHeLa CellsHistocompatibility Antigens Class IIHLA-D AntigensHLA-DR AntigensHumansLysosomal Membrane ProteinsLysosomesMacromolecular SubstancesMembrane GlycoproteinsStaining and LabelingVacuolesConceptsHLA-DRClass II moleculesLysosomal marker LAMP-1HLA-DMII moleculesLysosome-like compartmentsPresentation to T cellsChediak-Higashi syndrome cellsLoading compartmentClass II MHC moleculesSteady-state levelsClass I MHC moleculesSurface class II moleculesDisease statesEndocytic pathwayCell surface class II moleculesChediak-Higashi syndromeLysosomal morphologyEnlarged vacuolesLysosomal biogenesisLAMP-1Immune deficiencyPresence of HLA-DMT cellsAg presentation
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