2025
Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery
Fallon J, Hashemaghaie M, Peterson C, Tran D, Wu S, Valdes J, Pedicini N, Adams M, Soltis M, Mansour W, Wright M, Raghunathan K, Treggiari M, Sasannejad C, Devinney M. Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery. BMJ Open 2025, 15: e091099. PMID: 40081971, PMCID: PMC11907038, DOI: 10.1136/bmjopen-2024-091099.Peer-Reviewed Original ResearchConceptsNon-cardiac surgeryTotal sleep timeEfficacy of suvorexantRandomised controlled trialsTwo-sample t-testPostoperative sleepOlder patientsAssociated with prolonged hospitalizationDelirium severityDecrease delirium severityIncreased total sleep timeStudy drug dosePlacebo-controlled trialPostoperative inpatient stayLong-term cognitive impairmentFood and Drug AdministrationOlder surgical patientsPostoperative sleep disturbancePrimary endpoint dataRisk of deliriumT-testOral suvorexantInstitutional review boardPostoperative delirium severityOrexin-1
2004
Patterns and predictors of sleep pattern disturbance after cardiac surgery
Redeker NS, Ruggiero J, Hedges C. Patterns and predictors of sleep pattern disturbance after cardiac surgery. Research In Nursing & Health 2004, 27: 217-224. PMID: 15264261, DOI: 10.1002/nur.20023.Peer-Reviewed Original ResearchConceptsSleep pattern disturbanceCardiac surgeryPostoperative weekPreoperative New York Heart Association functional classNew York Heart Association functional classYork Heart Association functional classPattern disturbancePittsburgh Sleep Quality IndexCardiac surgery patientsSleep Quality IndexPostoperative sleepPostoperative periodSurgery patientsPreoperative periodSleep disturbancesWrist actigraphPreoperative sleepSleep patternsSleep variablesFunctional classSleepSurgeryT3T4Weeks
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