A Polynesian-specific missense CETP variant alters the lipid profile
Moors J, Krishnan M, Sumpter N, Takei R, Bixley M, Cadzow M, Major T, Phipps-Green A, Topless R, Merriman M, Rutledge M, Morgan B, Carlson J, Zhang J, Russell E, Sun G, Cheng H, Weeks D, Naseri T, Reupena M, Viali S, Tuitele J, Hawley N, Deka R, McGarvey S, de Zoysa J, Murphy R, Dalbeth N, Stamp L, Taumoepeau M, King F, Wilcox P, Rapana N, McCormick S, Minster R, Merriman T, Leask M. A Polynesian-specific missense CETP variant alters the lipid profile. Human Genetics And Genomics Advances 2023, 4: 100204. PMID: 37250494, PMCID: PMC10209881, DOI: 10.1016/j.xhgg.2023.100204.Peer-Reviewed Original ResearchConceptsPopulation-specific genetic variantsGenomic studiesGenetic analysisFunction mutationsVariant altersGenetic determinantsGenetic variantsMinor alleleCETP deficiencyGenomicsHigher HDLLipid profileTraitsSequencingLow LDL-C levelsMutationsAllelesLDL-C levelsSerum lipid profileCopiesPolymorphismAssociatesLower LDLCardiovascular diseaseVariants
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