2012
Role of RhoA-Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes
Gao Y, Smith E, Ker E, Campbell P, Cheng EC, Zou S, Lin S, Wang L, Halene S, Krause DS. Role of RhoA-Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes. Developmental Cell 2012, 22: 573-584. PMID: 22387001, PMCID: PMC3306542, DOI: 10.1016/j.devcel.2011.12.019.Peer-Reviewed Original ResearchConceptsGEF-H1Efficient platelet productionExchange factor GEF-H1Guanine exchange factorGEF-H1 knockdownDevelopment of aneuploidyGEF-H1 expressionMK polyploidizationExchange factorPloidy defectsAberrant mitosisDevelopmental processesExogenous expressionPolyploidizationRhoA activationEndomitotic cyclePrimary cellsUnknown mechanismMechanistic insightsECT2EndomitosisAneuploid cancersPlatelet productionMegakaryocytesDownregulation
2001
Roads to polyploidy: The megakaryocyte example
Ravid K, Lu J, Zimmet JM, Jones MR. Roads to polyploidy: The megakaryocyte example. Journal Of Cellular Physiology 2001, 190: 7-20. PMID: 11807806, DOI: 10.1002/jcp.10035.Peer-Reviewed Original ResearchConceptsCell cycleHigher ploidyHaploid chromosome numberGroup of genesEndomitotic cell cycleChromosome numberMammalian cellsCell physiologyDifferent cell cyclesAnaphase BS phaseMultiple copiesCell typesPlatelet precursorsPolyploidyGenesMegakaryocytesPloidyPolyploidizationCytokinesisInsectsCellsMitosisPlantsPhysiology
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