Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma
Panou V, Gadiraju M, Wolin A, Weipert C, Skarda E, Husain A, Patel J, Rose B, Zhang S, Weatherly M, Nelakuditi V, Knight Johnson A, Helgeson M, Fischer D, Desai A, Sulai N, Ritterhouse L, Røe O, Turaga K, Huo D, Segal J, Kadri S, Li Z, Kindler H, Churpek J. Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma. Journal Of Clinical Oncology 2018, 36: jco.2018.78.520. PMID: 30113886, PMCID: PMC6804864, DOI: 10.1200/jco.2018.78.5204.Peer-Reviewed Original ResearchConceptsCancer susceptibility genesMalignant mesotheliomaGermline mutationsSusceptibility genesSignificant proportion of patientsFrequency of germline mutationsAsbestos exposureCancer susceptibility mutationsHomologous recombination pathway genesGermline genetic testingProportion of patientsAssociated with decreased oddsNoncancer control populationCancer diagnosisPeritoneal MMBAP1 mutationsDNA damage sensingPleural sitesClinical predictorsHomologous recombination pathwayMM casesNext-generation sequencingGermline DNASusceptibility mutationsTumor sequencing
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