Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD
Leuenroth SJ, Bencivenga N, Chahboune H, Hyder F, Crews CM. Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD. Nephrology Dialysis Transplantation 2010, 25: 2187-2194. PMID: 20139063, PMCID: PMC2902895, DOI: 10.1093/ndt/gfp777.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAntineoplastic Agents, AlkylatingCell ProliferationCyclin-Dependent Kinase Inhibitor p21Disease Models, AnimalDisease ProgressionDiterpenesEpoxy CompoundsGTP-Binding ProteinsIntegrasesKidneyMiceMice, Mutant StrainsMutationMyxovirus Resistance ProteinsPhenanthrenesPolycystic Kidney, Autosomal DominantTime FactorsTRPP Cation ChannelsConceptsAutosomal dominant polycystic kidney diseaseCyst formationModel of ADPKDEnd-stage renal failureBlood urea nitrogen levelsPostnatal days P10Vehicle-treated animalsNumber of microcystsUrea nitrogen levelsDominant polycystic kidney diseaseNumerous rodent modelsInducible mouse modelPolycystic kidney diseaseCystic burdenPkd1-deficient miceRenal functionDrug development studiesRenal failureLiver cystsKidney diseaseDaily injectionsCyst progressionDisease progressionNovel therapiesRodent models
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