An Ancient Transcription Factor Initiates the Burst of piRNA Production during Early Meiosis in Mouse Testes
Li X, Roy C, Dong X, Bolcun-Filas E, Wang J, Han B, Xu J, Moore M, Schimenti J, Weng Z, Zamore P. An Ancient Transcription Factor Initiates the Burst of piRNA Production during Early Meiosis in Mouse Testes. Molecular Cell 2013, 50: 67-81. PMID: 23523368, PMCID: PMC3671569, DOI: 10.1016/j.molcel.2013.02.016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArgonaute ProteinsBiological EvolutionChickensEndodeoxyribonucleasesFeedback, PhysiologicalGene Expression ProfilingGene Expression Regulation, DevelopmentalGenotypeHigh-Throughput Nucleotide SequencingMaleMeiosisMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutPachytene StagePhenotypeProto-Oncogene Proteins c-mybRNA, Small InterferingSpermatogenesisTestisTrans-ActivatorsTranscription, GeneticTranscriptional ActivationConceptsPIWI-interacting RNAsPachytene PIWI interacting RNAsPiRNA pathway proteinsPiRNA productionMouse testisA-mybPiRNA precursor transcriptionPiRNA genesPiRNA biogenesis factorPathway proteinsCoherent feedforward loopDivergence of birdsSmall silencing RNAsAdult mouse testisAnimal germ cellsPostnatal spermatogenesisSuppress transposonsPiRNA functionMature spermPrecursor transcriptsBiogenesis factorsPrecursor RNARegulatory circuitsRooster testesEarly meiosis
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