2021
Exosomes as Emerging Biomarker Tools in Neurodegenerative and Neuropsychiatric Disorders—A Proteomics Perspective
Mathew B, Mansuri MS, Williams KR, Nairn AC. Exosomes as Emerging Biomarker Tools in Neurodegenerative and Neuropsychiatric Disorders—A Proteomics Perspective. Brain Sciences 2021, 11: 258. PMID: 33669482, PMCID: PMC7922222, DOI: 10.3390/brainsci11020258.Peer-Reviewed Original ResearchProtein dynamic rangeDifferent cell typesProteomic perspectiveRNA speciesExosome proteomicsDisease biomarker discoveryIsolation of exosomesProteomics researchCell typesPhysiological statusExosomesCell of originNovel reservoirVariable tissueBiomarker discoveryProteinProtein detectionProtein biomarkersCurrent progressProteomicsBiomarker toolSpeciesLow amountsRapid rateNeuropsychiatric disorders
2015
Profiling of urinary proteins in Karan Fries cows reveals more than 1550 proteins
Bathla S, Rawat P, Baithalu R, Yadav M, Naru J, Tiwari A, Kumar S, Balhara A, Singh S, Chaudhary S, Kumar R, Lotfan M, Behare P, Phulia S, Mohanty T, Kaushik J, Nallapeta S, Singh I, Ambatipudi S, Mohanty A. Profiling of urinary proteins in Karan Fries cows reveals more than 1550 proteins. Journal Of Proteomics 2015, 127: 193-201. PMID: 26021477, DOI: 10.1016/j.jprot.2015.05.026.Peer-Reviewed Original ResearchConceptsGene OntologyIn-gelTwo-dimensional gel electrophoresisFunctional significanceKaran Fries cowsIn-solution digestion methodProtease inhibitor activityAmmonium sulphateGel electrophoresisNon-invasive sourceBiological processesProtein extractsTryptic digests of proteinsProteinProteomicsHealthy cowsIn-gel digestion methodPhysiological statusDigestibility of proteinUrinary proteomeInhibitor activityCowsCytoscapeCoagulation cascadeGenes
1989
Regulation of Chloride Channels by Protein Kinase C in Normal and Cystic Fibrosis Airway Epithelia
Li M, McCann J, Anderson M, Clancy J, Liedtke C, Nairn A, Greengard P, Welsch M. Regulation of Chloride Channels by Protein Kinase C in Normal and Cystic Fibrosis Airway Epithelia. Science 1989, 244: 1353-1356. PMID: 2472006, DOI: 10.1126/science.2472006.Peer-Reviewed Original ResearchConceptsProtein kinase CChloride channelsKinase CApical membrane chloride channelMembrane chloride channelCystic fibrosis cellsMembrane proteinsCell-free membraneCystic fibrosis airway epitheliaChloride secretionIntact cellsPhorbol esterPhysiological statusDefective regulationAirway epithelial cellsEpithelial cellsCellsRegulationChannel inactivationCystic fibrosisActivationCalcium concentrationLow calcium concentrationsProteinAirway epithelium
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