Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis
Morton J, Mongeau M, Klimstra D, Morris J, Lee Y, Kawaguchi Y, Wright C, Hebrok M, Lewis B. Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 5103-5108. PMID: 17372229, PMCID: PMC1828712, DOI: 10.1073/pnas.0701158104.Peer-Reviewed Original ResearchConceptsShh signalingActivation of phosphatidylinositol 3-kinase signalingSonic hedgehogPhosphatidylinositol 3-kinase signalingStability of Bcl-2Pancreatic duct epithelial cellsActivation of sonic hedgehogPancreatic tumorigenesisActivated K-rasDuct epithelial cellsCell cycle regulator cyclin D1Epithelial cellsBcl-x(LTranscriptional regulationRegulator cyclin D1Dependence of tumor cellsPancreatic tumor developmentProliferation of pancreatic duct epithelial cellsBcl-2Signaling pathwayResistance to therapeutic interventionsShhShh expressionCyclin D1Stages of pancreatic carcinogenesis
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