Hepatic PEMT Expression Decreases with Increasing NAFLD Severity
Piras I, Raju A, Don J, Schork N, Gerhard G, DiStefano J. Hepatic PEMT Expression Decreases with Increasing NAFLD Severity. International Journal Of Molecular Sciences 2022, 23: 9296. PMID: 36012560, PMCID: PMC9409182, DOI: 10.3390/ijms23169296.Peer-Reviewed Original ResearchConceptsPhosphatidylethanolamine N-methyltransferaseNonalcoholic fatty liver diseaseFine-mapping analysisPostmenopausal womenIncreasing severity of NAFLDHepatic fibrosisHigh risk of nonalcoholic fatty liver diseaseIncreasing severity of fibrosisNonalcoholic fatty liver disease patientsSeverity of nonalcoholic fatty liver diseaseRisk of nonalcoholic fatty liver diseaseIncreasing severityNonalcoholic fatty liver disease severityCohort of patientsSeverity of fibrosisGenetic variantsAssociated with NAFLD riskProducts of phosphatidylcholineSpectrum of nonalcoholic fatty liver diseaseGene expressionNormal liver histologyPhosphatidylcholine synthesisFatty liver diseaseN-methyltransferaseNASH patients
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