2018
Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia
Chan L, Shojaee S, Hurtz C, Auer F, Chen Z, Cosgun K, Geng H, Sadras T, White D, Muschen M. Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia. Blood 2018, 132: 568. DOI: 10.1182/blood-2018-99-115536.Peer-Reviewed Original ResearchEvolutionary trajectoriesColony formation abilityCompetitive fitnessCommitment stepPre-B cell receptorDivergent evolutionary trajectoriesUpstream kinase MEKNormal B cell developmentOncogenic signal transductionInducible ablationActivation of STAT5B cell developmentEmpty vector controlActivation of ERKCentral oncogenic driverB-cell transformationImmature B cellsSignal transductionFormation abilityKinase MEKPhosphorylation of ERKGrowth factor receptorPatient-derived preAlternative pathwayERK activity
2013
Circadian phase‐dependent effect of nitric oxide on L‐type voltage‐gated calcium channels in avian cone photoreceptors
Ko M, Shi L, Huang C, Grushin K, Park S, Ko G. Circadian phase‐dependent effect of nitric oxide on L‐type voltage‐gated calcium channels in avian cone photoreceptors. Journal Of Neurochemistry 2013, 127: 314-328. PMID: 23895452, PMCID: PMC4112736, DOI: 10.1111/jnc.12384.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCalcium Channels, L-TypeChick EmbryoCircadian RhythmCyclic GMPCyclic GMP-Dependent Protein KinasesImmunoenzyme TechniquesIn Vitro TechniquesMAP Kinase Signaling SystemNitratesNitric OxideNitric Oxide DonorsNitric Oxide SynthaseOncogene Protein v-aktPatch-Clamp TechniquesPhosphatidylinositol 3-KinasesRetinal Cone Photoreceptor CellsRNA, Small InterferingSignal TransductionS-Nitroso-N-AcetylpenicillamineTransfectionConceptsCircadian output pathwayProtein kinase BL-VGCC currentsProtein kinase GL-type voltage-gated calcium channelsRas-mitogen-activated protein kinaseKinase BCircadian controlVoltage-gated calcium channelsPhase-dependent regulationLight-dependent mannerExtracellular signal-regulated kinaseCone photoreceptorsSignal-regulated kinaseProtein expressionCircadian phase-dependent effectEndogenous circadian oscillatorOutput pathwaysPhosphorylation of ERKProtein kinasePhosphorylation stateNeural nitric oxide synthaseSubunit expressionCircadian regulationCircadian oscillatorThe nuclear receptor PPARγ regulates T cell tolerance and germinal center formation via generation of follicular helper T cells (P4545)
Choi J, Park H, Choi J, Senejani A, Tobiasova Z, Kim D, Bothwell A. The nuclear receptor PPARγ regulates T cell tolerance and germinal center formation via generation of follicular helper T cells (P4545). The Journal Of Immunology 2013, 190: 197.7-197.7. DOI: 10.4049/jimmunol.190.supp.197.7.Peer-Reviewed Original ResearchT cell toleranceFollicular helper T cellsHelper T cellsT cellsGerminal center formationDeficient T cellsCell toleranceHelper T cell subsetsExpression of IkBαPeroxisome proliferator-activated receptor gammaT cell subsetsProliferator-activated receptor gammaWild-type T cellsType T cellsRole of PPARγNuclear receptor PPARγFunction of PPARγPhosphorylation of ERKTfh generationTh9 cellsIL-17Kidney inflammationAutoantibody productionCell subsetsCenter formation
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