2020
Light microscopy of proteins in their ultrastructural context
M’Saad O, Bewersdorf J. Light microscopy of proteins in their ultrastructural context. Nature Communications 2020, 11: 3850. PMID: 32737322, PMCID: PMC7395138, DOI: 10.1038/s41467-020-17523-8.Peer-Reviewed Original ResearchConceptsUltrastructural contextLocal protein densityConventional confocal microscopeCellular nanoarchitectureOptical contrastSpecific proteinsElectron microscopyFluorescence microscopyLight microscopyProteinBulk labelingProtein densityConfocal microscopeStandard light microscopyIntracellular spaceMicroscopyProteomeCellsNanoscaleMicroscopeNew principleDiscoveryLabelingPhysical expansionDensity
2017
Expansion mini-microscopy: An enabling alternative in point-of-care diagnostics
Zhang Y, Santiago G, Alvarez M, Schiff S, Boyden E, Khademhosseini A. Expansion mini-microscopy: An enabling alternative in point-of-care diagnostics. Current Opinion In Biomedical Engineering 2017, 1: 45-53. PMID: 29062977, PMCID: PMC5650103, DOI: 10.1016/j.cobme.2017.03.001.Peer-Reviewed Original ResearchCare diagnosticsLow cost imagerHigh-end microscopesMiniature imagersSuper-resolution imagingPOC detectionPOC diagnosticsExpansion microscopyBiological specimensLow complexityConventional microscopePortable imagerPortable instrumentationBiological samplesDiagnostic technologiesMicroscopeWidespread applicationInexpensive deviceSingle-cell parasitesTremendous progressDiagnosticsRecent advancesMicroscope hardwareLow-resource regionsPhysical expansion
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