2002
Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line.
Shi C, Barnes S, Coca-Prados M, Kelly ME. Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line. Investigative Ophthalmology & Visual Science 2002, 43: 1525-32. PMID: 11980870.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TransformedChloride ChannelsCiliary BodyEnzyme ActivationEnzyme InhibitorsEpithelial CellsPatch-Clamp TechniquesPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPhosphoprotein PhosphatasesPhosphorylationProtein-Tyrosine KinasesRabbitsSignal TransductionConceptsProtein tyrosine kinasesProtein tyrosine kinase inhibitorTyrosine kinaseOkadaic acidPP-1Ciliary epithelial cellsHyposmotic stimulationC-Src tyrosine kinasePI3KProtein phosphatase inhibitorPKC inhibitorEpithelial cellsSrc tyrosine kinaseCiliary epithelial cell linePhosphatidylinositol-3 kinase inhibitorKinase inhibitorsProtein phosphatasePhosphatase inhibitorCl- currentEpithelial cell lineNonpigmented ciliary epithelial cellsCell swellingKinasePKC activatorTyrosine kinase inhibitors
1999
Phosphatidylinositol-3 Kinase Dependent MAP Kinase Activation via p21ras in Endothelial Cells Exposed to Cyclic Strain
Ikeda M, Kito H, Sumpio B. Phosphatidylinositol-3 Kinase Dependent MAP Kinase Activation via p21ras in Endothelial Cells Exposed to Cyclic Strain. Biochemical And Biophysical Research Communications 1999, 257: 668-671. PMID: 10208841, DOI: 10.1006/bbrc.1999.0532.Peer-Reviewed Original ResearchMeSH KeywordsAndrostadienesAnimalsAortaCalcium-Calmodulin-Dependent Protein KinasesCattleCells, CulturedChromonesEndothelium, VascularEnzyme ActivationGuanosine TriphosphateHemodynamicsMorpholinesOncogene Protein p21(ras)Phosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPhosphorylationSignal TransductionStress, MechanicalTime FactorsWortmanninConceptsERK1/2 activationPhosphatidylinositol-3 kinase inhibitorMAP kinase activationExtracellular signal-regulated protein kinases 1Endothelial cellsMechanical stretchKinase inhibitorsERK1/2 phosphorylationEffect of wortmanninPossible involvementHemodynamic forcesProtein kinase 1ActivationKinase 1Upstream pathwaysRapid activationKinase activationSignal transduction pathwaysP21ras activationLY294002ERK1 activationERK2 activation
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