Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure
Nakamura M, Odanovic N, Nakada Y, Dohi S, Zhai P, Ivessa A, Yang Z, Abdellatif M, Sadoshima J. Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure. Cardiovascular Research 2020, 117: 2365-2376. PMID: 33070172, PMCID: PMC8861266, DOI: 10.1093/cvr/cvaa298.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxybutyric AcidAnimal FeedAnimalsCells, CulturedDiet, High-Protein Low-CarbohydrateDiet, KetogenicDietary CarbohydratesDisease Models, AnimalGlycogen Synthase Kinase 3 betaHeart FailureHemodynamicsHypertrophy, Left VentricularMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacNutritive ValueRatsRats, WistarSignal TransductionTOR Serine-Threonine KinasesVentricular Function, LeftVentricular RemodelingConceptsPressure overloadHeart failureDevelopment of cardiac hypertrophyLow-carbohydrateCardiac-specific knockout miceHigh carbohydrate control dietPhenylephrine-induced hypertrophyHypertensive cardiac remodelingDevelopment of pathological hypertrophyTransverse aortic constrictionWild-type miceAnti-hypertrophic mechanismsHearts of micePathological cardiac growthGSK-3bDietary carbohydrate restrictionSystolic dysfunctionAortic constrictionCardiac hypertrophyCardiac remodelingLC dietKnockout micePathological hypertrophyCarbohydrate restrictionCardiac pathology
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