2025
Protein codes promote selective subcellular compartmentalization
Kilgore H, Chinn I, Mikhael P, Mitnikov I, Van Dongen C, Zylberberg G, Afeyan L, Banani S, Wilson-Hawken S, Lee T, Barzilay R, Young R. Protein codes promote selective subcellular compartmentalization. Science 2025, 387: 1095-1101. PMID: 39913643, PMCID: PMC12034300, DOI: 10.1126/science.adq2634.Peer-Reviewed Original ResearchConceptsProtein sequencesSubcellular compartmentsDiverse subcellular compartmentsProtein language modelsAmino acid sequenceProtein codingAcid sequenceSubcellular localizationDiverse proteinsHuman proteinsSubcellular compartmentalizationFolding codePathological mutationsCompartment localizationProteinSequenceCompartmentMutationsAminoNucleolusCompartmentalizationCells
2014
Complex Relationship between Ligand Binding and Dimerization in the Epidermal Growth Factor Receptor
Bessman NJ, Bagchi A, Ferguson KM, Lemmon MA. Complex Relationship between Ligand Binding and Dimerization in the Epidermal Growth Factor Receptor. Cell Reports 2014, 9: 1306-1317. PMID: 25453753, PMCID: PMC4254573, DOI: 10.1016/j.celrep.2014.10.010.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorLigand bindingExtracellular regionGrowth factor receptorIntact epidermal growth factor receptorEGFR extracellular regionComplex allosteric regulationExtracellular epidermal growth factor receptorFactor receptorLigand-binding affinityAllosteric regulationReceptor dimerizationEGFR dimerizationAllosteric linkagePathological mutationsOncogenic mutationsNegative cooperativityMutationsDimerizationUnexpected relationshipBindingSpecific ligandsPivotal roleRecent advancesReceptors
2000
DNA diagnosis of PKD 1 gene in cerebral aneurysm patients
Honmou O, Akiyama Y, Sasaki M, Uede T, Hashi K. DNA diagnosis of PKD 1 gene in cerebral aneurysm patients. Nosotchu 2000, 22: 457. DOI: 10.3995/jstroke.22.457.Peer-Reviewed Original ResearchAmino acid proteinCerebral aneurysm patientsPolycystic kidney diseaseProtein-carbohydrate interactionsSingle-strand conformation polymorphism methodAneurysm patientsAcid proteinGenomic DNASequence analysisConformation polymorphism methodNovel pathological mutationsPathological mutationsGenesDirect sequence analysisProgressive cyst formationCerebral aneurysm formationExtracellular compartmentMutationsGenetic disordersAortic dissectionKidney diseasePolycystic diseaseHeart valve defectsDNA diagnosisAneurysm formation
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