Induced clustered nanoconfinement of superparamagnetic iron oxide in biodegradable nanoparticles enhances transverse relaxivity for targeted theranostics
Ragheb RR, Kim D, Bandyopadhyay A, Chahboune H, Bulutoglu B, Ezaldein H, Criscione JM, Fahmy TM. Induced clustered nanoconfinement of superparamagnetic iron oxide in biodegradable nanoparticles enhances transverse relaxivity for targeted theranostics. Magnetic Resonance In Medicine 2013, 70: 1748-1760. PMID: 23401099, PMCID: PMC3834165, DOI: 10.1002/mrm.24622.Peer-Reviewed Original ResearchConceptsSuperparamagnetic iron oxideTransverse relaxivityAvailable superparamagnetic iron oxide nanoparticlesIron oxideSuperparamagnetic iron oxide nanoparticlesDrug deliveryHigh transverse relaxivityIron oxide nanoparticlesPolymer matrixEncapsulated iron oxidesMultifunctional nanoparticlesOxide nanoparticlesTheranostic capabilityBiodegradable nanoparticlesNanoparticlesSurface ligandsSurface modificationDiagnostic agentsCellular targetingEncapsulated drugsDual modalityTheranosticsParticle formulationContrast agentsFatty acid ligands
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