2016
The lymphotoxin β receptor is a potential therapeutic target in renal inflammation
Seleznik G, Seeger H, Bauer J, Fu K, Czerkowicz J, Papandile A, Poreci U, Rabah D, Ranger A, Cohen CD, Lindenmeyer M, Chen J, Edenhofer I, Anders HJ, Lech M, Wüthrich RP, Ruddle NH, Moeller MJ, Kozakowski N, Regele H, Browning JL, Heikenwalder M, Segerer S. The lymphotoxin β receptor is a potential therapeutic target in renal inflammation. Kidney International 2016, 89: 113-126. PMID: 26398497, DOI: 10.1038/ki.2015.280.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCell LineChemokinesDisease Models, AnimalEpithelial CellsFemaleGlomerulonephritis, IGAHumansImmunoglobulinsKidney GlomerulusKidney TubulesLigandsLupus NephritisLymphocytesLymphotoxin beta ReceptorLymphotoxin-alphaLymphotoxin-betaMaleMesangial CellsMiceMiddle AgedRNA, MessengerSignal TransductionTranscriptomeConceptsTubular epithelial cellsParietal epithelial cellsEpithelial cellsRenal injuryLTβR signalingTherapeutic targetGlomerular immune complex depositionLymphotoxin β receptor (LTβR) signalingImproved renal functionSerum autoantibody titersHuman tubular epithelial cellsImmune complex depositionMurine lupus modelsProgressive kidney diseaseSuitable therapeutic targetPreclinical mouse modelsDifferent renal compartmentsPotential therapeutic targetΒ Receptor SignalingLymphotoxin β receptorAutoantibody titersRenal inflammationLupus modelsRenal functionRenal biopsy
2012
Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidney
Lier N, Gresko N, Di Chiara M, Loffing-Cueni D, Loffing J. Immunofluorescent localization of the Rab-GAP protein TBC1D4 (AS160) in mouse kidney. Histochemistry And Cell Biology 2012, 138: 101-112. PMID: 22466139, DOI: 10.1007/s00418-012-0944-1.Peer-Reviewed Original ResearchConceptsIntracellular traffickingRab-GTPase activating proteinInsulin-dependent traffickingParietal epithelial cellsRenal transport proteinsExtracellular fluid homeostasisGlucose transporter GLUT4Epithelial sodium channel ENaCDeficient miceImmunohistochemical studyRabbit polyclonal antibodySkeletal muscle cellsBowman's capsuleWater channel AQP2Proximal tubulesRenal ionSpecific marker proteinsKidney homogenatesHenle's loopSodium channel ENaCFluid homeostasisThick limbMuscle cellsMouse kidney homogenatesMouse kidney
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