Pathologic Response to Preoperative Chemotherapy in Colorectal Liver Metastases: Fibrosis, not Necrosis, Predicts Outcome
Poultsides G, Bao F, Servais E, Hernandez-Boussard T, DeMatteo R, Allen P, Fong Y, Kemeny N, Saltz L, Klimstra D, Jarnagin W, Shia J, D’Angelica M. Pathologic Response to Preoperative Chemotherapy in Colorectal Liver Metastases: Fibrosis, not Necrosis, Predicts Outcome. Annals Of Surgical Oncology 2012, 19: 2797-2804. PMID: 22476753, DOI: 10.1245/s10434-012-2335-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCamptothecinChemotherapy, AdjuvantColorectal NeoplasmsFemaleFibrosisHepatectomyHumansIrinotecanKaplan-Meier EstimateLiver NeoplasmsMaleMiddle AgedMucinsMultivariate AnalysisNecrosisOrganoplatinum CompoundsOxaliplatinPreoperative CarePrognosisRetrospective StudiesSingle-Blind MethodConceptsColorectal liver metastasis resectionColorectal liver metastasesPreoperative chemotherapyPathological responseAcellular mucinHepatic arterial infusion chemotherapyResponse to preoperative chemotherapyAssociation of treatment responseArterial infusion chemotherapyDisease-specific survivalAssociated with survivalRate of necrosisInfusion chemotherapyLiver metastasesTreatment responseChemotherapyFibrosisPercentage necrosisResectionPatientsChemotherapy patientsNecrosisPathological alterationsPredicting OutcomeDominant response patterns
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