2025
American Foregut Society White Paper Report on the Use of Potassium-Competitive Acid Blockers in the Treatment of Gastroesophageal Reflux Disease
Spechler S, Kolb J, Dunbar K, Gyawali C, Bell R, Fass R, Katz P, Laine L, Lipham J, Schnoll-Sussman F, Souza R, Yadlapati R, Kahrilas P. American Foregut Society White Paper Report on the Use of Potassium-Competitive Acid Blockers in the Treatment of Gastroesophageal Reflux Disease. Foregut The Journal Of The American Foregut Society 2025 DOI: 10.1177/26345161251325874.Peer-Reviewed Original ResearchPotassium-competitive acid blockerGastroesophageal reflux diseaseProton pump inhibitorsTreatment of gastroesophageal reflux diseaseReflux diseaseAcid blockerSuppression of gastric acid secretionNon-erosive reflux diseaseGastroesophageal reflux disease treatmentInhibit gastric acid productionTreat gastroesophageal reflux diseaseGastric acid secretionRAND/UCLA appropriateness methodologyGastric acid productionPanelistsAcid productionErosive esophagitisPump inhibitorsFDA approvalAcid secretionForegut surgeonsClinical practiceMedical treatment
2023
Genetic Variation and Sensory Perception of a Pediatric Formulation of Ibuprofen: Can a Medicine Taste Too Good for Some?
Mennella J, Kan M, Lowenthal E, Saraiva L, Mainland J, Himes B, Pepino M. Genetic Variation and Sensory Perception of a Pediatric Formulation of Ibuprofen: Can a Medicine Taste Too Good for Some? International Journal Of Molecular Sciences 2023, 24: 13050. PMID: 37685855, PMCID: PMC10487938, DOI: 10.3390/ijms241713050.Peer-Reviewed Original ResearchConceptsGenetic ancestryEuropean genetic ancestryTaste receptor genesIndependent of ancestryAfrican genetic ancestryGenetic variationFormulations of ibuprofenEpigenetic factorsAncestryReceptor geneDouble-blind cohort studyUrge to coughPerception of palatabilityRisk of accidental ingestionPersonality variationCohort studyPediatric formulationsSensory phenotypesThroat sensationChemesthetic sensationsMedicinal tasteTingling sensationPanelistsAdult panelistsDiverse populations
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