Gastric bypass alters diurnal feeding behavior and reprograms hepatic clock to regulate endogenous glucose flux
Ye Y, Abu El Haija M, Obeid R, Herz H, Tian L, Linden B, Chu Y, Guo D, Levine D, Cedernaes J, Rahmouni K, Bass J, Mokadem M. Gastric bypass alters diurnal feeding behavior and reprograms hepatic clock to regulate endogenous glucose flux. JCI Insight 2023, 8: e166618. PMID: 36787197, PMCID: PMC10070113, DOI: 10.1172/jci.insight.166618.Peer-Reviewed Original ResearchConceptsRoux-en-Y gastric bypassGastric bypassGlucose fluxDiurnal feeding behaviorEffects of Roux-en-Y gastric bypassEating behaviorsMolecular clockWeight-independent effectsRoux-en-YGlucose metabolismWeight loss effectsDiurnal eating patternReporter mouse modelHepatic glucose productionHepatic clockClock activityHepatic glucose fluxesPair-feeding experimentsPeripheral clocksBariatric proceduresClock oscillatorGlucose homeostasisFeeding behaviorMutant miceFood intake
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