Single-Nucleotide Polymorphisms in p53 Pathway and Aggressiveness of Prostate Cancer in a Caucasian Population
Sun T, Lee G, Oh W, Pomerantz M, Yang M, Xie W, Freedman M, Kantoff P. Single-Nucleotide Polymorphisms in p53 Pathway and Aggressiveness of Prostate Cancer in a Caucasian Population. Clinical Cancer Research 2010, 16: 5244-5251. PMID: 20855462, PMCID: PMC2970725, DOI: 10.1158/1078-0432.ccr-10-1261.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkers, TumorCarcinomaCell Cycle ProteinsCohort StudiesDisease ProgressionGenetic Predisposition to DiseaseGenetics, PopulationHumansMaleMiddle AgedNeoplasm InvasivenessNuclear ProteinsPolymorphism, Single NucleotideProstatic NeoplasmsProto-Oncogene ProteinsProto-Oncogene Proteins c-mdm2Signal TransductionTumor Suppressor Protein p53Ubiquitin ThiolesteraseUbiquitin-Specific Peptidase 7White PeopleConceptsProstate cancer aggressivenessProstate cancer developmentSingle-nucleotide polymorphismsGleason scoreRadical prostatectomyProstate cancerCancer aggressivenessAssociated with high Gleason scoreAggressiveness of prostate cancerCancer developmentEarly onset prostate cancerSNP309T alleleP53 pathwayAssociation of single-nucleotide polymorphismsHigh Gleason scoreP53 Arg72Pro polymorphismProstate cancer cohortTime of diagnosisP53 pathway genesFunctional single-nucleotide polymorphismsStatistically significant associationHigher D'AmicoArg72Pro polymorphismClinicopathological variablesPathological variables
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