2021
The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs
Tesfaye E, Martinez-Terroba E, Bendor J, Winkler L, Olivero C, Chen K, Feldser DM, Zamudio JR, Dimitrova N. The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2025539118. PMID: 34326251, PMCID: PMC8346867, DOI: 10.1073/pnas.2025539118.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinogenesisCell Line, TumorCell ProliferationCellular SenescenceDNA DamageE2F Transcription FactorsGene Expression Regulation, NeoplasticGenome-Wide Association StudyMiceNeoplasmsProto-Oncogene Proteins c-mycRNA, Long NoncodingSignal TransductionStress, PhysiologicalTumor Suppressor Protein p53ConceptsOncogenic contextPermanent cell cycle arrestP53-induced lncRNAsP53 transcriptional responseMYC target genesTumor suppressor mechanismRepression of E2FP53-binding siteP53-dependent senescenceTumor-type specificCell cycle arrestTranscriptional responseProliferative arrestTarget genesMurine cancer cell linesTranscriptional signatureRegulatory axisTumor typesCycle arrestP53 functionDistinct tumor typesFunctional investigationDownstream mediatorP53 pathwayCancer cell lines
2012
Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver
Furlan A, Lamballe F, Stagni V, Hussain A, Richelme S, Prodosmo A, Moumen A, Brun C, del Barco Barrantes I, Arthur JS, Koleske AJ, Nebreda AR, Barilà D, Maina F. Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver. Journal Of Hepatology 2012, 57: 1292-1298. PMID: 22889954, PMCID: PMC3571726, DOI: 10.1016/j.jhep.2012.07.044.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell SurvivalCyclin-Dependent Kinase Inhibitor p21HepatocytesLiverMicep38 Mitogen-Activated Protein KinasesPhosphorylationProto-Oncogene Proteins c-ablProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-metTranscription, GeneticTumor Suppressor Protein p53ConceptsHepatocyte survivalRT-PCR arrayHGF/METEmbryonic liverCell survivalP53 transcriptional responseP53 axisP53-dependent cell deathEmbryonic hepatocytesMdm2 upregulationAbstractTextPathway modulationLiverP53 pathwaySurvivalMetSSurvival propertiesTranscriptional responseSurvival genesDeathAIMSCell deathP53 phosphorylationPresent studyP38MAPK
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply