2025
Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype
Berardi D, Farrell G, AlSultan A, McCulloch A, Hall N, Sousa R, Jimenez M, Selman C, Bellantuono I, Johnson C, Rattray Z, Rattray N. Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype. Aging Cell 2025, 24: e70127. PMID: 40530891, PMCID: PMC12341781, DOI: 10.1111/acel.70127.Peer-Reviewed Original ResearchSenescence inductionLabel-free proteomicsDNA damage markersRedox circuitsCell inductionImpaired proteostasisP21 levelsTherapeutic strategiesCellular phenotypesMetabolic phenotypeMetabolic reprogrammingProteomic heterogeneityMetabolic shiftSenescence markersProteomic profilingMetabolic processesSenescence biomarkersDamage markersProtein levelsSenescenceSubphenotypesSenescence modelInfluence cellsPhenotypeInduction
2014
LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint
Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T. LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint. Molecular Cell 2014, 54: 777-790. PMID: 24857549, PMCID: PMC4103188, DOI: 10.1016/j.molcel.2014.04.025.Peer-Reviewed Original ResearchConceptsG1/S checkpointGene expressionS checkpointPolycomb target genesGlobal gene expressionP53 transcriptional networkTarget gene expressionTumor suppressor pathwayConditional knockout mouse modelP53 tumor suppressor pathwayChromatin stateTranscriptional networksKnockout mouse modelNeighboring genesMRNA translationProtein stabilityTarget genesP21 transcriptionSuppressor pathwayAdditional phenotypesGenesP21 levelsLincRNA-p21P21 expressionCoactivator
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply