2022
Social evolution of shared biofilm matrix components
Tai J, Mukherjee S, Nero T, Olson R, Tithof J, Nadell C, Yan J. Social evolution of shared biofilm matrix components. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2123469119. PMID: 35771939, PMCID: PMC9271185, DOI: 10.1073/pnas.2123469119.Peer-Reviewed Original ResearchConceptsBiofilm matrix componentsCooperative public goodsMatrix componentsBiofilm formationBiofilm matrix proteinsMatrix productionSocial evolution theoryBiofilm spatial structureCell surface adhesionEvolutionary timescalesCell clustersRelatedness coefficientsBacterial communitiesBiofilm habitatAdhesion proteinsEvolutionary advantageEvolutionary stabilityMatrix proteinsAssociated analysis toolsDiffusible compoundsHost environmentSocial evolutionUbiquitous modeOutstanding questionsProtein
2021
Phase separation in immune signalling
Xiao Q, McAtee CK, Su X. Phase separation in immune signalling. Nature Reviews Immunology 2021, 22: 188-199. PMID: 34230650, PMCID: PMC9674404, DOI: 10.1038/s41577-021-00572-5.Peer-Reviewed Original ResearchConceptsGene I proteinImmune signaling pathwaysCyclic GMP-AMP synthaseSubstantial conformational changesNew biophysical principleGMP-AMP synthaseCell receptorB cell receptorCytosolic eventsSignal transductionImmune signalingSignaling pathwaysI proteinConformational changesLigand engagementDownstream adaptorsInterferon genesImmune receptorsBiophysical principlesLiquid-liquid phase separationFunctional consequencesT cell receptorPathogenic stimuliSpatial reorganizationOutstanding questionsMajor advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs
Alabi SB, Crews C. Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs. Journal Of Biological Chemistry 2021, 296: 100647. PMID: 33839157, PMCID: PMC8131913, DOI: 10.1016/j.jbc.2021.100647.Peer-Reviewed Original ResearchConceptsProtein degradationProtein degradation pathwaysProteolysis targeting chimera (PROTAC) technologyUbiquitin-proteasome systemEndo-lysosomal pathwaySmall molecule inhibitorsDruggable spaceChemical toolsInnovative chemical toolMolecular glueChimera technologyProtein moleculesDegradation pathwayOutstanding questionsCurrent understandingMajor advancesPathwayAutophagyPROTACsDegradationCellsInhibitorsAdvances
2019
3571 Expression profile of the ribbon synapse protein Ribeye in the zebrafish
Frederick C, Zenisek D. 3571 Expression profile of the ribbon synapse protein Ribeye in the zebrafish. Journal Of Clinical And Translational Science 2019, 3: 11-11. PMCID: PMC6799612, DOI: 10.1017/cts.2019.29.Peer-Reviewed Original ResearchAdult zebrafish retinaZebrafish retinaRibeye proteinsZebrafish tissuesWestern blotProtein isoformsLarval zebrafishZebrafish larvaeSynapse-associated proteinsExpression profilesZebrafishSplice variantsSynapse functionProteinDistinct mechanismsIsoformsLarvalOutstanding questionsHair cellsSynaptic disorderNovel therapeutic interventionsExpressionNeuromastsSynaptic dysregulationPronounced expression
2016
Readthrough transcription: How are DoGs made and what do they do?
Vilborg A, Steitz JA. Readthrough transcription: How are DoGs made and what do they do? RNA Biology 2016, 14: 632-636. PMID: 26861889, PMCID: PMC5449079, DOI: 10.1080/15476286.2016.1149680.Peer-Reviewed Original ResearchConceptsDoG inductionDownstream of genesMammalian gene expressionLevel of transcriptionPervasive transcriptionIntergenic transcriptionTranscription terminationPossible molecular mechanismsTranscriptional readthroughOsmotic stressGene expressionMolecular mechanismsEndoplasmic reticulumTranscriptionIP3 receptorOutstanding questionsTranscriptsBiogenesisGenomeInductionReadthroughGenesCalcium releaseReticulumMechanism
2013
FisB mediates membrane fission during sporulation in Bacillus subtilis
Doan T, Coleman J, Marquis KA, Meeske AJ, Burton BM, Karatekin E, Rudner DZ. FisB mediates membrane fission during sporulation in Bacillus subtilis. Genes & Development 2013, 27: 322-334. PMID: 23388828, PMCID: PMC3576517, DOI: 10.1101/gad.209049.112.Peer-Reviewed Original ResearchConceptsMother cell membraneMembrane fissionPhagocytic-like processBacillus subtilisLarger mother cellProkaryotic cell biologyMother cell cytoplasmCell membraneSmaller foresporeSite of fissionFission machineryMembrane topologyMembrane remodelingExtracytoplasmic domainMother cellsFission proteinsSpore formationCell biologySporulating cellsForesporeFisBCell cytoplasmRemarkable specificityOutstanding questionsSubtilis
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