2024
Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α
Li G, Wang A, Tang W, Fu W, Tian Q, Jian J, Lata M, Hettinghouse A, Ding Y, Wei J, Zhao X, Wang M, Dong Q, Liu C, Xu Y. Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α. Genes & Diseases 2024, 12: 101221. PMID: 39559258, PMCID: PMC11570241, DOI: 10.1016/j.gendis.2024.101221.Peer-Reviewed Original ResearchPostmenopausal osteoporosisEstrogen receptorReceptor AEstrogen signalingTreatment of postmenopausal osteoporosisOvariectomy-induced bone lossEstrogen-mediated inhibitionRegulation of bone mineral densityBone mineral densityEstrogen receptor aPGRN-deficient miceInhibition of osteoclastogenesisPostmenopausal womenEstrogen deficiencyMineral densityLoss of progranulinEstrogen regulationBone lossBone massPositive feedback regulatory loopBone resorptionOsteoporosisTherapeutic approachesEstrogenOsteoporosis model
2016
Anabolic actions of Notch on mature bone
Liu P, Ping Y, Ma M, Zhang D, Liu C, Zaidi S, Gao S, Ji Y, Lou F, Yu F, Lu P, Stachnik A, Bai M, Wei C, Zhang L, Wang K, Chen R, New M, Rowe D, Yuen T, Sun L, Zaidi M. Anabolic actions of Notch on mature bone. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e2152-e2161. PMID: 27036007, PMCID: PMC4839423, DOI: 10.1073/pnas.1603399113.Peer-Reviewed Original ResearchConceptsOvariectomy-induced bone lossEGFP reporter miceStimulation of NotchBone lossAnabolic actionAnabolic responseReporter miceMature micePresenilin 1Bone healingLigand Jagged1Bone formationTime pointsMiceAdult boneGenetic disruptionMature boneBone matrixConditional activationNotch expressionTerminal osteoblast differentiationNotch activationOsteoblast differentiationBoneOsteocytes
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