Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing
Raddatz M, Huffstater T, Bersi M, Reinfeld B, Madden M, Booton S, Rathmell W, Rathmell J, Lindman B, Madhur M, Merryman W. Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing. Arteriosclerosis Thrombosis And Vascular Biology 2020, 40: e153-e165. PMID: 32295422, PMCID: PMC7285853, DOI: 10.1161/atvbaha.120.314360.Peer-Reviewed Original ResearchConceptsValve cellsMurine aortic valvesAortic valve diseaseCalcific aortic valve diseaseBone marrow genotypeOsteogenic calcificationAortic valve cellsMacrophage-driven inflammationValve diseaseMacrophage maturationMacrophage recruitmentMacrophage interactionsCell secretionCell calcificationAortic valveTherapeutic targetSTAT3Flow cytometryExpression of MHCIIMaturationBone marrow transplantRecruitmentGenotypesMacrophagesCells
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