2023
Immunity in the balance: Fatal disseminated adenovirus infection in a patient undergoing plasma exchange and immunosuppressive chemotherapy for anti‐glomerular basement membrane disease
Jacobs J, Villalba C, Stendahl K, Tormey C, Abels E. Immunity in the balance: Fatal disseminated adenovirus infection in a patient undergoing plasma exchange and immunosuppressive chemotherapy for anti‐glomerular basement membrane disease. Journal Of Clinical Apheresis 2023, 38: 770-777. PMID: 37698143, DOI: 10.1002/jca.22088.Peer-Reviewed Original ResearchConceptsTherapeutic plasma exchangeAnti-glomerular basement membrane diseaseAnti-GBM diseasePlasma exchangeMembrane diseaseDaily therapeutic plasma exchangeFatal disseminated adenovirus infectionRare autoinflammatory conditionsMulti-organ failureStandard therapeutic regimenDisseminated adenovirus infectionDisseminated adenovirus diseasePotential opportunistic infectionsPotential adverse effectsApheresis guidelinesAdenovirus diseaseOrgan inflammationProfound immunosuppressionAutoantibody productionOpportunistic infectionsTherapeutic regimenAutoinflammatory conditionsImmunosuppressive chemotherapyUnusual infectionsClose surveillance
2015
Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus
Teichmann LL, Cullen JL, Kashgarian M, Dong C, Craft J, Shlomchik MJ. Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus. Immunity 2015, 42: 552-565. PMID: 25786178, PMCID: PMC4456685, DOI: 10.1016/j.immuni.2015.02.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAutoantibodiesCD11c AntigenCell DifferentiationFemaleGene Expression RegulationHumansInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinKidneyLungLupus NephritisMice, TransgenicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionT-Lymphocytes, Helper-InducerConceptsInducible T-cell costimulatorOrgan inflammationICOS ligandFollicular helper cell differentiationLupus-prone MRLT-cell costimulatorHelper cell differentiationLupus pathologyLung inflammationAutoantibody formationAutoantibody productionMurine lupusInflamed organsLymphoid tissueT cellsB cellsPathogenic relevanceInflammationLupusPI3K-AktSelective ablationCell differentiationNonredundant rolePotent promoterCells
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