The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank
Don J, Schork A, Glusman G, Rappaport N, Cummings S, Duggan D, Raju A, Hellberg K, Gunn S, Monti S, Perls T, Lapidus J, Goetz L, Sebastiani P, Schork N. The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank. GeroScience 2024, 46: 3911-3927. PMID: 38451433, PMCID: PMC11226417, DOI: 10.1007/s11357-024-01107-1.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPolygenic risk scoresDisease-Associated VariantsPolygenic scoresParental lifespanLarge-scale genome-wide association studiesUK Biobank (UKBEffects of disease-associated variantsTests of associationUK BiobankGenetic architecturePopulation structureAssociation studiesPolygenic basisAssociated with parental lifespanDisease traitsPolygenic componentGenetic variantsRisk scoreDisease susceptibilityHuman longevityGenetic predispositionHealthTraitsHealth span
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply