Cryo-EM structure of the brine shrimp mitochondrial ATP synthase suggests an inactivation mechanism for the ATP synthase leak channel
Kumar A, da Fonseca Rezende e Mello J, Wu Y, Morris D, Mezghani I, Smith E, Rombauts S, Bossier P, Krahn J, Sigworth F, Mnatsakanyan N. Cryo-EM structure of the brine shrimp mitochondrial ATP synthase suggests an inactivation mechanism for the ATP synthase leak channel. Cell Death & Differentiation 2025, 1-18. PMID: 40108410, DOI: 10.1038/s41418-025-01476-w.Peer-Reviewed Original ResearchMitochondrial permeability transition poreATP synthaseMammalian ATP synthaseOpening of mitochondrial permeability transition poreMitochondrial inner membraneMitochondrial ATP synthaseC-terminal regionPermeability transition poreCryo-EM structureCrustacean Artemia franciscanaSingle-particle cryo-electron microscopyCryo-electron microscopyMammalian mitochondriaAccumulate large amountsCa2+-inducedInner membraneLeak channelsOuter membranePermeability transitionTransition poreE subunitCell deathMitochondrial dysfunctionMolecular mechanismsCa2+
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