OXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment
Hong H, Mbah N, Shan M, Loesel K, Lin L, Sajjakulnukit P, Correa L, Andren A, Lin J, Hayashi A, Magnuson B, Chen J, Li Z, Xie Y, Zhang L, Goldstein D, Carty S, Lei Y, Opipari A, Argüello R, Kryczek I, Kamada N, Zou W, Franchi L, Lyssiotis C. OXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment. Science Immunology 2022, 7: eabm8182. PMID: 36399539, PMCID: PMC9853437, DOI: 10.1126/sciimmunol.abm8182.Peer-Reviewed Original ResearchConceptsOxidative phosphorylationBcl-xLApoptotic resistanceIncreased mitochondrial fitnessTargeting oxidative phosphorylationMediators of host defenseMitochondrial oxidative phosphorylationTumor microenvironmentOxidative phosphorylation conditionsAdoptive T cell therapyFunction in vivoImmune responseMurine model of melanomaEffector function in vivoGlutamine anaplerosisOPA-1T-cell therapyCell fateCD4 T cellsImpaired effector functionsAdoptive transfer experimentsMitochondrial fitnessCellular persistenceModel of melanomaT cell proliferation
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