A Multi-step Transcriptional and Chromatin State Cascade Underlies Motor Neuron Programming from Embryonic Stem Cells
Velasco S, Ibrahim M, Kakumanu A, Garipler G, Aydin B, Al-Sayegh M, Hirsekorn A, Abdul-Rahman F, Satija R, Ohler U, Mahony S, Mazzoni E. A Multi-step Transcriptional and Chromatin State Cascade Underlies Motor Neuron Programming from Embryonic Stem Cells. Cell Stem Cell 2016, 20: 205-217.e8. PMID: 27939218, PMCID: PMC5291817, DOI: 10.1016/j.stem.2016.11.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCellular ReprogrammingChromatinDNAEmbryonic Stem CellsEnhancer Elements, GeneticGenetic LociMiceModels, BiologicalMotor NeuronsNucleotide MotifsPromoter Regions, GeneticProtein BindingSequence Analysis, RNASingle-Cell AnalysisTime FactorsTranscription FactorsTranscription, GeneticConceptsTranscription factorsGene expressionOverexpression of transcription factorsControl cell fateCell fate programsOnecut transcription factorsNeuronal programTF bindingChromatin stateRegulatory regionsCell fateRegulatory stepTranscriptional modulationNeuronal enhancersEmbryonic stem cellsCell differentiationChromatinGenesCell programBindingNgn2ExpressionCellsOnecutStem cells
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