2008
Common Familial Colorectal Cancer Linked to Chromosome 7q31: A Genome-Wide Analysis
Neklason D, Kerber R, Nilson D, Anton-Culver H, Schwartz A, Griffin C, Lowery J, Schildkraut J, Evans J, Tomlinson G, Strong L, Miller A, Stopfer J, Finkelstein D, Nadkarni P, Kasten C, Mineau G, Burt R. Common Familial Colorectal Cancer Linked to Chromosome 7q31: A Genome-Wide Analysis. Cancer Research 2008, 68: 8993-8997. PMID: 18974144, PMCID: PMC2927856, DOI: 10.1158/0008-5472.can-08-1376.Peer-Reviewed Original ResearchConceptsGenetic regionsLinkage analysisGenome-wide analysisFamilial cancer genesNovel susceptibility genesNonparametric linkage analysisShort tandem repeat markersCommon Familial Colorectal CancerFine mappingRepeat markersTandem repeat markersCancer genesChromosome 7q31Odds (LOD) scoreGenesSusceptibility genesSignificant linkagePenetrant genesDNA samplesFamilial colorectal cancerRelative pairsLociCancer onsetColorectal cancer onsetCancer syndromes
2006
Molecular Genetic Analysis of Two Large Kindreds With Intracranial Aneurysms Demonstrates Linkage to 11q24-25 and 14q23-31
Ozturk AK, Nahed BV, Bydon M, Bilguvar K, Goksu E, Bademci G, Guclu B, Johnson MH, Amar A, Lifton RP, Gunel M. Molecular Genetic Analysis of Two Large Kindreds With Intracranial Aneurysms Demonstrates Linkage to 11q24-25 and 14q23-31. Stroke 2006, 37: 1021-1027. PMID: 16497978, DOI: 10.1161/01.str.0000206153.92675.b9.Peer-Reviewed Original ResearchConceptsGenome-wide linkage analysisMolecular genetic analysisGenetic analysisSusceptibility genesLinkage analysisSimple Mendelian traitPolymorphic microsatellite markersSignificant LOD scoreGenomic regionsMendelian traitsMicrosatellite markersCandidate lociGene chipOutlier approachOdds (LOD) scoreGenesChromosome 11q24Chromosome 11qAvailable family membersLOD scoreGenetic heterogeneityIa geneLociSib pairsGenetic factors
1990
Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on chromosome 20.
Summar M, Phillips J, Battey J, Castiglione C, Kidd K, Maness K, Weiffenbach B, Gravius T. Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on chromosome 20. Endocrinology 1990, 4: 947-50. PMID: 1978246, DOI: 10.1210/mend-4-6-947.Peer-Reviewed Original ResearchConceptsLinkage relationshipsChromosome 20Restriction fragment length polymorphismCentre d'Etude du Polymorphisme Humain (CEPH) collectionFragment length polymorphismShort armAnonymous DNA segmentsSomatic cell hybridsLength polymorphismDistal short armSame neurosecretory granulesStructural geneTranscriptional associationsHuman genomeCell hybridsDNA segmentsLocus mapsMultilocus linkage analysisClose physical relationshipLinkage analysisSouthern blotOdds (LOD) scoreLociGenesClose linkage
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