The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains
LeBrun D, Matthews B, Feldman B, Cleary M. The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains. Oncogene 1997, 15: 2059-2067. PMID: 9366523, DOI: 10.1038/sj.onc.1201367.Peer-Reviewed Original ResearchConceptsE2A-Pbx1 proteinsE2A-PBX1Chimeric oncoprotein E2a-Pbx1RNA polymerase IIFunctional nuclear compartmentsSubcellular localization patternsAssociated with DNAEnhanced DNA bindingTranscriptional relevanceNascent transcriptsGene E2APolymerase IIPBX1 proteinNuclear transcription factorsHomeodomain proteinsE2A-HLFSubcellular localizationDNA replicationDNA bindingActivation domainTranscriptional activityProtein elementsTranscription factorsNuclear compartmentNuclear domains
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