PGLYRP2 drives hepatocyte-intrinsic innate immunity by trapping and clearing hepatitis B virus
Li Y, Ma H, Zhang Y, He T, Li B, Ren H, Feng J, Sheng J, Li K, Qian Y, Wang Y, Zhao H, He J, Li H, Wu H, Yao Y, Shi M. PGLYRP2 drives hepatocyte-intrinsic innate immunity by trapping and clearing hepatitis B virus. Journal Of Clinical Investigation 2025, 135: e188083. PMID: 39946201, PMCID: PMC11996887, DOI: 10.1172/jci188083.Peer-Reviewed Original ResearchHepatitis B virusHBV clearanceSpontaneous clearance of hepatitis B virusB virusClear hepatitis B virusClearance of hepatitis B virusHepatitis B virus infectionSpontaneous HBV clearanceAnti-HBV treatmentDNA-binding domainInhibit HBV replicationCovalently closed circular DNAPattern recognition receptorsPotential therapeutic strategyFunctional cureSpontaneous clearanceHost-virus interactionsAge-dependent expressionPathogenic variantsPGRP domainHBV replicationTherapeutic strategiesRecognition receptorsNucleocytoplasmic translocationPGLYRP2
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