Associations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity
SooHoo J, Davis C, Han A, Jinwala Z, Gelernter J, Feinn R, Kranzler H. Associations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity. Psychological Medicine 2025, 55: e132. PMID: 40314172, PMCID: PMC12094658, DOI: 10.1017/s0033291725001163.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Childhood ExperiencesAlcoholismBlack or African AmericanFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansMaleMarijuana AbuseMiddle AgedMultifactorial InheritanceOpioid-Related DisordersSeverity of Illness IndexSubstance-Related DisordersWhiteYoung AdultConceptsSubstance use disorder severitySubstance use disordersAdverse childhood experiencesGene-by-environment interactionsSubstance Use InitiationPolygenic scoresOpioid use disorderUse disorderEUR individualsAssociated with AUD severityCannabis use disorderAssociated with adverse childhood experiencesSeverity of alcoholismLatent factorsSubstance use disorder riskGene-environment correlationAssociation of childhood adversityAssociation of adverse childhood experiencesAncestry groupsAUD severityDisorder severityChildhood adversityPolygenic riskChildhood experiencesEnvironmental influences
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