1990
The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein.
Herbst RS, Boczko EM, Darnell JE, Babiss LE. The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein. Molecular And Cellular Biology 1990, 10: 3896-3905. PMID: 2370857, PMCID: PMC360900, DOI: 10.1128/mcb.10.8.3896.Peer-Reviewed Original ResearchConceptsDNA-binding sitesMouse albumin enhancerNovel DNA-binding proteinAlbumin enhancerNegative regulatory domainDNA-binding proteinsNegative regulatory regionDNA-binding activityNegative regulatory elementPositive-acting elementsOrientation-independent fashionRegulatory domainRegulatory regionsAlbumin gene transcriptionGene transcriptionRegulatory elementsEnhancer functionNew proteinsCap siteTissue specificityAlbumin geneCell typesProteinNonhepatic cellsEnhancer
1986
Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders.
Mimori T, Hardin JA, Steitz JA. Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. Journal Of Biological Chemistry 1986, 261: 2274-2278. PMID: 3511059, DOI: 10.1016/s0021-9258(17)35929-x.Peer-Reviewed Original ResearchConceptsKu proteinNovel DNA-binding proteinAnti-Ku antibodiesDNA-binding proteinsHigh molecular weight nucleic acidsExtracts of cellsKu antigenDa subunitChromatinHeLa cellsScleroderma-polymyositis overlap syndromeBiochemical natureProteinWeight nucleic acidsLarge formNucleic acidsOverlap syndromeRheumatic disordersCertain patientsAntibodiesAntigenAutoantibodiesCellsImmunoaffinity column chromatographyPatients
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