2007
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
Suchting S, Freitas C, le Noble F, Benedito R, Bréant C, Duarte A, Eichmann A. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 3225-3230. PMID: 17296941, PMCID: PMC1805603, DOI: 10.1073/pnas.0611177104.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmyloid Precursor Protein SecretasesAnimalsCalcium-Binding ProteinsEndothelium, Vasculargamma-Aminobutyric AcidImmunohistochemistryIn Situ HybridizationIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, Mutant StrainsReceptors, Vascular Endothelial Growth FactorRetinal VesselsSignal TransductionTriglyceridesVascular Endothelial Growth Factor AConceptsTip cell formationEndothelial tip cell formationTip cellsNotch ligand DeltaCell formationCell marker genesEndothelial tip cellsVessel branchingLigand DeltaExpression of Dll4Vascular network formationTransmembrane ligandsNotch receptorsMarker genesNegative regulatorAngiogenic sproutingVEGF receptor 2VEGF stimulationFilopodia extensionGamma-secretase inhibitorsGrowth factor VEGFVascular sproutingPharmacological inhibitionDll4Heterozygous deletion
1999
Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian
Qi H, Rand M, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S. Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian. Science 1999, 283: 91-94. PMID: 9872749, DOI: 10.1126/science.283.5398.91.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell LineCells, CulturedDisintegrinsDrosophilaDrosophila ProteinsFemaleIntracellular Signaling Peptides and ProteinsLigandsMaleMembrane ProteinsMetalloendopeptidasesMolecular Sequence DataMutationNeuronsProtein Processing, Post-TranslationalReceptors, NotchSignal TransductionTransfectionConceptsLigand DeltaMetalloprotease KuzbanianCell fate determinationNotch ligand DeltaFate determinationNotch proteinsTransmembrane ligandsNotch activityProcessing eventsExtracellular fragmentGenetic analysisNotch ligandsSurface receptorsKuzbanianAdjacent cellsSoluble formBroad spectrumNotchSignalingProteinLigandsCellsFragmentsVivoReceptors
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