2019
Pharmacodynamic Responses to CC-90009, a Novel Cereblon E3 Ligase Modulator, in a Phase I Dose-Escalation Study in Relapsed or Refractory Acute Myeloid Leukemia (R/R AML)
Fan J, Wang H, Couto S, Yao T, Uy G, Zeidan A, Minden M, Montesinos P, DeAngelo D, Altman J, Koprivnikar J, Vyas P, Fløisand Y, Vidriales M, Gjertsen B, Buchholz T, Pourdehnad M, Pierce D. Pharmacodynamic Responses to CC-90009, a Novel Cereblon E3 Ligase Modulator, in a Phase I Dose-Escalation Study in Relapsed or Refractory Acute Myeloid Leukemia (R/R AML). Blood 2019, 134: 2547. DOI: 10.1182/blood-2019-124291.Peer-Reviewed Original ResearchNovel cereblon E3 ligase modulatorCereblon E3 ligase modulatorPeripheral blood mononuclear cellsCC-90009T cellsPharmacodynamic responseCelgene CorporationDaiichi SankyoSpeakers bureauR AMLAML blastsIntegrated stress responseBlast cellsDay 1Dose levelsPhase I dose-escalation studyRefractory acute myeloid leukemiaI dose-escalation studyAdvisory CommitteeBone marrow core biopsiesAntileukemic activitySeattle GeneticsPhase IHigh-dose cohortNorwegian Cancer Society
1978
IMMUNOLOGICAL STUDIES OF HUMAN Ia-LIKE ANTIGENS11This work was supported by research grants from the U.S. Public Health Service (N.I.H. AI-10736 and AI-09576). A.F. is a fellow of the Medical Research Council, Canada. M.G.'s involvement was sponsored in part by the Dutch Organization for the Advancement of Pure Research. B.S.'s work was supported in part by the Norwegian Cancer Society
Kaufman J, Fuks A, Giphart M, Solheim B, Strominger J. IMMUNOLOGICAL STUDIES OF HUMAN Ia-LIKE ANTIGENS11This work was supported by research grants from the U.S. Public Health Service (N.I.H. AI-10736 and AI-09576). A.F. is a fellow of the Medical Research Council, Canada. M.G.'s involvement was sponsored in part by the Dutch Organization for the Advancement of Pure Research. B.S.'s work was supported in part by the Norwegian Cancer Society. 1978, 235-241. DOI: 10.1016/b978-0-12-483260-2.50030-6.Peer-Reviewed Original Research
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