Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging
Nithianandam V, Bukhari H, Leventhal M, Battaglia R, Dong X, Fraenkel E, Feany M. Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging. Nature Communications 2023, 14: 7034. PMID: 37923712, PMCID: PMC10624868, DOI: 10.1038/s41467-023-42822-1.Peer-Reviewed Original ResearchConceptsAmyloid precursor proteinPrecursor proteinNormal function of APPFunction of amyloid precursor proteinPathogenesis of Alzheimer's diseaseRelevant to Alzheimer's diseaseAlzheimer's diseaseDrosophila orthologMutant fliesTauopathy modelGenetic screeningAB peptideCellular signalingCellular pathwaysProteomic studiesMitochondrial functionProteostasisNeurodegenerative diseasesIntegrated analysisLipid metabolismRegulating autophagyNucleic acidsSingle cellsAmyloidTGFB signaling
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply