NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline
Osterburg AR, Nelson RL, Yaniv BZ, Foot R, Donica W, Nashu MA, Liu H, Wikenheiser-Brokamp KA, Moss J, Gupta N, McCormack FX, Borchers MT. NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline. JCI Insight 2016, 1: e87270. PMID: 27734028, PMCID: PMC5053147, DOI: 10.1172/jci.insight.87270.Peer-Reviewed Original ResearchConceptsLung function declineNK cellsLAM pathogenesisFunction declineNeoplastic smooth muscle cellsNK cell activating receptorsNKG2D surface expressionRare lung diseaseInnate immune systemSmooth muscle cellsExpiratory volumePulmonary functionLAM patientsLung diseaseActivating receptorsLAM lesionsImmune surveillanceImmune systemBinding protein 2Ligand expressionPulmonary nodulesLymphangioleiomyomatosisMuscle cellsPatientsCyst formation
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