1999
Biochemical and behavioral anxiolytic-like effects of R(+)HA-966 at the level of the ventral tegmental area in rats
Morrow B, Elsworth J, Zito C, Roth R. Biochemical and behavioral anxiolytic-like effects of R(+)HA-966 at the level of the ventral tegmental area in rats. Psychopharmacology 1999, 143: 227-234. PMID: 10353424, DOI: 10.1007/s002130050941.Peer-Reviewed Original ResearchConceptsVentral tegmental areaHA-966Expression sessionsIntra-VTADopamine metabolismTegmental areaGlycine/NMDA receptor complexPrefrontal cortexMesoprefrontal dopamine neuronsAnxiolytic-like effectsAnxiolytic-like actionDopamine cell bodiesNMDA receptor complexWeak partial agonistMedial prefrontal cortexStress-induced activationCannula implantationDopamine neuronsControl ratsLocal injectionPartial agonistRatsCell bodiesPsychological stressorsStress-induced changes
1995
R-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures
Morrow B, Taylor J, Roth R. R-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures. Brain Research 1995, 673: 165-169. PMID: 7757472, DOI: 10.1016/0006-8993(94)01456-r.Peer-Reviewed Original ResearchConceptsGlycine/NMDA receptorHA-966Locomotor sensitizationLocomotor activationNMDA receptorsCocaine administrationSubsequent challenge doseLocomotor stimulant propertiesNMDA receptor complexAcute stimulant effectsChallenge doseReverse toleranceRepeated administrationAcute doseCocaine exposureStimulant effectsGlycine receptorsStimulant propertiesCocaineSensitizationAdministrationReceptorsReceptor complexAntagonistDose
1994
The NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat
Goldstein L, Rasmusson A, Bunney B, Roth R. The NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat. Journal Of Neuroscience 1994, 14: 4937-4950. PMID: 8046462, PMCID: PMC6577203, DOI: 10.1523/jneurosci.14-08-04937.1994.Peer-Reviewed Original ResearchConceptsStress-induced increaseNMDA glycine-site antagonistsDA utilizationGlycine modulatory siteGlycine site antagonistHA-966Conditioned stressPrefrontal cortexCortical dopamineSite antagonistNucleus accumbensControl animalsModulatory siteMedial prefrontal cortical dopamineLateral prefrontal cortexPrefrontal cortical dopamineSerum corticosterone levelsNMDA receptor complexPost-traumatic stress disorderMedial prefrontal cortexNeurotransmitter ratiosRegional dopamineSerotonin utilizationSerum corticosteroneNMDA receptors
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply