2016
Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment
Levey DF, Niculescu EM, Le-Niculescu H, Dainton HL, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Molecular Psychiatry 2016, 21: 768-785. PMID: 27046645, DOI: 10.1038/mp.2016.31.Peer-Reviewed Original ResearchConceptsFuture hospitalizationConvergent functional genomics approachSuicide completersPrimary end pointSingle blood biomarkerTop biomarkersReceiver-operating characteristic areaRisk prediction scoreClinical risk assessmentDisorder participantsIndependent test cohortForm of APPProphylactic benefitNeurotrophic effectsBlood biomarkersSleep abnormalitiesPsychiatric hospitalizationHospitalizationMood disordersTest cohortCandidate biomarkersSuicide completionSuicidal ideationDrug lithiumChronic stress
2014
Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders
Coplan JD, Fulton SL, Reiner W, Jackowski A, Panthangi V, Perera TD, Gorman JM, Huang YY, Tang CY, Hof PR, Kaffman A, Dwork AJ, Mathew SJ, Kaufman J, Mann JJ. Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders. Frontiers In Behavioral Neuroscience 2014, 8: 440. PMID: 25566007, PMCID: PMC4274982, DOI: 10.3389/fnbeh.2014.00440.Peer-Reviewed Original ResearchEarly life stressRight hippocampal volumeHippocampal volumeCerebrospinal fluidFractional anisotropySerotonin neurotransmissionMonoamine metabolitesNeurotrophic activitySmaller right hippocampal volumeAnxiety disordersHigh cerebrospinal fluidElevated cerebrospinal fluidWhite matter fractional anisotropyEffects of ELSLife stressMonths of ageReduced fractional anisotropyWM fractional anisotropySerotonin deficitVFD subjectsDorsal rapheMacaque modelCSF tapsInternal capsuleNeurotrophic effects
2006
Galanin and galanin‐like peptide modulate neurite outgrowth via protein kinase C‐mediated activation of extracellular signal‐related kinase
Hawes JJ, Narasimhaiah R, Picciotto MR. Galanin and galanin‐like peptide modulate neurite outgrowth via protein kinase C‐mediated activation of extracellular signal‐related kinase. European Journal Of Neuroscience 2006, 23: 2937-2946. PMID: 16819983, DOI: 10.1111/j.1460-9568.2006.04828.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell DifferentiationCells, CulturedDose-Response Relationship, DrugDrug InteractionsEmbryo, MammalianEnzyme ActivationEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesGalaninGalanin-Like PeptideNeuritesNeuronsProtein Kinase CRatsReceptors, GalaninReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStem CellsConceptsGalanin-like peptideProtein kinase CNervous systemNeurite outgrowthAdult hippocampal progenitor cellsAbility of galaninKinase CERK phosphorylationHippocampal progenitor cellsNeuronal cell line PC12Central nervous systemModulates Neurite OutgrowthExtracellular signal-related kinase (ERK) phosphorylationConcentration-dependent mannerNerve injuryNeuropeptide galaninNeurotrophic effectsExtracellular signal-related kinaseReceptor subtypesNovel physiological roleAdult brainGalaninCell line PC12Signal-related kinaseProgenitor cells
1990
VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro
Kaiser P, Lipton S. VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro. Neuron 1990, 5: 373-381. PMID: 2169272, DOI: 10.1016/0896-6273(90)90173-d.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideNatural cell deathRGC survivalRetinal ganglion cell deathRetinal ganglion cell neuronsCell deathGanglion cell deathGanglion cell neuronsElectrical blockadePHI-27VIP10-28Intestinal peptideAfferent influencesNeurotrophic effectsNeonatal ratsTetrodotoxin blockadeVIP stimulationRetinal culturesCell neuronsIntact retinaAdenylate cyclaseNormal cell deathElectrical activityDeathRGCs
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