Investigating the Role of TDP-43 Microvasculopathy on Neurovascular unit Function in the Setting of COVID-19 and Alzheimer’s Disease and Related Dementias
Mathew S, Gopal P. Investigating the Role of TDP-43 Microvasculopathy on Neurovascular unit Function in the Setting of COVID-19 and Alzheimer’s Disease and Related Dementias. Physiology 2024, 39: 1266. DOI: 10.1152/physiol.2024.39.s1.1266.Peer-Reviewed Original ResearchTDP-43Alzheimer's diseaseRNA/DNA-binding protein TDP-43Human AD brainsUbiquitinated TDP-43TDP-43 fragmentsProtein TDP-43Non-autonomous effectsDevelopment of ADNeuronal tauAD brainPhosphorylated TDP-43Mammalian cellsTau expressionSARS-CoV-2Human brain samplesType IV collagenTDP-43 depositionNeurovascular unit functionProximity to capillariesPTDP-43Neurovascular unit cellsIV collagenTransendothelial migrationImmunofluorescence analysis
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