2012
Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK
Katz SG, Fisher JK, Correll M, Bronson RT, Ligon KL, Walensky LD. Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene 2012, 32: 4078-4085. PMID: 22986529, PMCID: PMC3529761, DOI: 10.1038/onc.2012.421.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsProapoptotic Bcl-2 family proteins BaxSubventricular zoneBcl-2 family proteins BaxProgenitor cellsLong-term pathophysiological consequencesMitochondrial outer membraneBax/BakDeletion of BaxStem cell nicheHigh-grade tumorsMultiple developmental abnormalitiesIntrinsic apoptotic pathwayOlfactory bulb regionNestin-positive cellsProgenitor cell poolCellular excessDeath stimuliLoss of functionHypercellular tumorOuter membraneTesticular tumorsCell nicheLong-term regulationApoptotic pathway
2007
A population of human brain parenchymal cells express markers of glial, neuronal and early neural cells and differentiate into cells of neuronal and glial lineages
Rieske P, Azizi S, Augelli B, Gaughan J, Krynska B. A population of human brain parenchymal cells express markers of glial, neuronal and early neural cells and differentiate into cells of neuronal and glial lineages. European Journal Of Neuroscience 2007, 25: 31-37. PMID: 17241264, DOI: 10.1111/j.1460-9568.2006.05254.x.Peer-Reviewed Original ResearchConceptsNestin-positive cellsGlial lineagesNestin expressionBetaIII-tubulinCells of glial lineageGrowth factorGlial fibrillary acidic protein (GFAP)-positive cellsCells of neuronal lineageNeurons in vitroBetaIII-tubulin expressionDown-regulating nestin expressionProgenitor cell characteristicsBrain parenchymal cellsRegulation of gene expressionCells expressing GFAPSerum-free mediumGFAP-positive cellsStem/progenitor cellsProliferative phaseNeuronal markersFibroblast growth factorMonolayer culture systemGFAP expressionNeuronal lineagePopulation of GFAP-positive cells
2001
Transplantation of Clonal Neural Precursor Cells Derived from Adult Human Brain Establishes Functional Peripheral Myelin in the Rat Spinal Cord
Akiyama Y, Honmou O, Kato T, Uede T, Hashi K, Kocsis J. Transplantation of Clonal Neural Precursor Cells Derived from Adult Human Brain Establishes Functional Peripheral Myelin in the Rat Spinal Cord. Experimental Neurology 2001, 167: 27-39. PMID: 11161590, DOI: 10.1006/exnr.2000.7539.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBrainBrain Tissue TransplantationCell DifferentiationCells, CulturedCerebral VentriclesClone CellsDemyelinating DiseasesFemaleGenes, ReporterHumansIntermediate Filament ProteinsMaleMiddle AgedMyelin SheathNerve Tissue ProteinsNestinNeural ConductionNeuronsRadiation Injuries, ExperimentalRatsRats, WistarSpinal CordStem Cell TransplantationStem CellsTransplantation, HeterologousConceptsAdult human brainRat spinal cordNestin-positive cellsNeural precursor cellsSpinal cordAdult rat spinal cordNormal conduction velocityHuman brainMitogen withdrawalSpinal cord resultsPrecursor cellsGlia-like cellsSchwann cell myelinationNeural progenitor cellsFunctional remyelinationP0 immunoreactivityRemyelinated axonsExtensive remyelinationCord resultsAnterior hornLateral ventricleSubventricular zoneMajority of cellsMyelin patternSchwann cells
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