Efficient evolution of human antibodies from general protein language models
Hie B, Shanker V, Xu D, Bruun T, Weidenbacher P, Tang S, Wu W, Pak J, Kim P. Efficient evolution of human antibodies from general protein language models. Nature Biotechnology 2023, 42: 275-283. PMID: 37095349, PMCID: PMC10869273, DOI: 10.1038/s41587-023-01763-2.Peer-Reviewed Original ResearchConceptsProtein language modelsDiverse protein familiesLaboratory evolutionProtein familyProtein structureBinding specificityRare mutationsSelection pressureAntibiotic resistanceNatural evolutionary strategyEnzyme activityHuman antibodiesMature antibodiesAffinity maturationProteinAntibody bindingBinding affinityMutationsBindingEvolutionary strategyAffinityAntibodiesSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2
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