Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire
Kwok WW, Tan V, Gillette L, Littell CT, Soltis MA, LaFond RB, Yang J, James EA, DeLong JH. Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire. The Journal Of Immunology 2012, 188: 2537-2544. PMID: 22327072, PMCID: PMC3997369, DOI: 10.4049/jimmunol.1102190.Peer-Reviewed Original ResearchConceptsT cellsMemory repertoireAg-specific T cellsNaive repertoireNaive precursor frequencyT cell responsesFrequency of precursorsProtective AgImmunized subjectsTCR usageNaive CD4Precursor frequencyEpitope specificityCell responsesMurine repertoireDifferent epitopesNonvaccineesVaccineesImmunodominanceEpitopesCellsHuman repertoireSubjectsCD4HLA
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