2025
Voltage-gated sodium channels in excitable cells as drug targets
Alsaloum M, Dib-Hajj S, Page D, Ruben P, Krainer A, Waxman S. Voltage-gated sodium channels in excitable cells as drug targets. Nature Reviews Drug Discovery 2025, 24: 358-378. PMID: 39901031, DOI: 10.1038/s41573-024-01108-x.Peer-Reviewed Original ResearchSodium channelsChannel subtypesControl action potential firingDevelopment of drugsDensity of voltage-gated sodiumExcitable cellsAction potential firingSubtype-specific drugsSodium channel subtypesVoltage-gated sodium channelsExpressing high densitiesVoltage-gated sodiumCardiac myocytesNav1.1-Nav1.9Potential firingCardiac disordersAction potentialsMuscle cellsMolecular targetsDrugSubtypesDrug developmentCellsDrug targetsMyocytes
2002
Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells
Takahashi K, Ouyang X, Komatsu K, Nakamura N, Hattori M, Baba A, Azuma J. Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochemical Pharmacology 2002, 64: 745-750. PMID: 12167494, DOI: 10.1016/s0006-2952(02)01250-9.Peer-Reviewed Original ResearchConceptsSodium tanshinone IIA sulfonateAngiotensin IITanshinone IIA sulfonateEffect of STSCultured neonatal rat cardiac cellsCardiac cellsCultured cardiac cellsS. miltiorrhiza extractImmediate early gene expressionNeonatal rat heartsAttenuates hypertrophyCardiovascular diseaseC-jun expressionRat cardiac cellsDiphenylformazan assayRat heartTherapeutic basisCardiac fibroblastsNeonatal rat cardiac cellsEarly gene expressionCultured myocytesHypertrophyTanshinone IIAExact mechanismMyocytes
2000
O-299 MOLECULAR CHARACTERIZATION OF CYCLICALL STRETCH-INDUCED HYPERTROPHY OF CARDIAC MYOCYTES AND HYPERPLASIA OF CARDIAC FIBROBLASTS
Yamauchi Y, Takahashi K, Ouyang X, Shikata E, Itoh T, Baba A, Azuma J. O-299 MOLECULAR CHARACTERIZATION OF CYCLICALL STRETCH-INDUCED HYPERTROPHY OF CARDIAC MYOCYTES AND HYPERPLASIA OF CARDIAC FIBROBLASTS. Journal Of Pharmacological Sciences 2000, 82: 116. DOI: 10.1016/s0021-5198(19)47932-8.Peer-Reviewed Original Research
1989
Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes
Bahinski A, Nairn A, Greengard P, Gadsby D. Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes. Nature 1989, 340: 718-721. PMID: 2475783, DOI: 10.1038/340718a0.Peer-Reviewed Original ResearchConceptsCyclic AMP-dependent protein kinaseAMP-dependent protein kinaseProtein kinaseChloride ion currentCatalytic subunitRegulatory proteinsKinase activationIon channelsKinaseChloride conductanceCalcium entrySingle-channel currentsCardiac myocytesCellsHeart cellsPhosphorylationAction potential repolarizationConductanceSubunitsProteinIntracellular dialysisMyocytesRegulationChannel currentsAdrenergic stimulation
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