Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance
Qi Y, Xu Z, Zhu Q, Thomas C, Kumar R, Feng H, Dostal D, White M, Baker K, Guo S. Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance. Diabetes 2013, 62: 3887-3900. PMID: 24159000, PMCID: PMC3806607, DOI: 10.2337/db13-0095.Peer-Reviewed Original ResearchConceptsIRS2 proteinGene expressionType 2 diabetesEnergy metabolism gene expressionInsulin resistanceMetabolic gene expressionBox class ODouble knockout miceHeart failureActivation of p38Chronic insulin exposureActivation of p38αMetabolism gene expressionProtein kinaseRole of IRS1Cellular metabolismMolecular mechanismsInsulin receptorNeonatal rat ventricular cardiomyocytesP38α MAPKCause heart failureCellular dysfunctionIRS1Myocardial insulin resistanceClass OChronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model
Thorn SL, Gollob MH, Harper ME, Beanlands RS, deKemp RA, DaSilva JN. Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model. EJNMMI Research 2013, 3: 48. PMID: 23829931, PMCID: PMC3707764, DOI: 10.1186/2191-219x-3-48.Peer-Reviewed Original ResearchMyocardial glucose uptakeCardiac glycogen storesSystolic functionInsulin resistanceAcute insulinMouse modelGlycogen storesDeoxyglucose positron emission tomographyProgressive conduction system diseaseGlucose uptakeSkeletal muscle glucose uptakeExcessive glycogen depositionDisease mouse modelMyocardial insulin resistanceMuscle glucose uptakeConduction system diseaseInsulin receptor expressionPositron emission tomographyPRKAG2 cardiac syndromeFrequent arrhythmiaInsulin stimulationMetabolic therapyReceptor expressionCardiac syndromeSystem diseases
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